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December 12, 2012

Personalized Medicine Through Integrated Next Generation Sequencing

Speaker for this Event:
  • Anup Madan, Ph.D., Director of Sequencing, Covance  Learn More
  • Increasing evidence demonstrates that multiple genomic aberrations such as single nucleotide variations, differential promoter methylation, copy number variations, etc. contribute to disease progression and play an active role in selecting populations of patients for target based therapeutic agents. Many biomarkers for drug safety and efficacy have been detected already, and the number is expected to increase significantly over the next few years. The move towards greater personalization of medicine also comes with challenges in the development of novel diagnostic and therapeutic tools in a complex framework. It assumes the use of genomic information is part of a translational continuum, which spans from basic to clinical research, preclinical and clinical trials.

    Next Generation Sequencing technologies can provide information on all of the different types of disease-causing alterations in the short turn-around-time required to screen patients for either clinical trials or for diagnostics in clinical settings. We are developing methods that allow us to identify various genomic alterations in a rapid-turn-around time using Glioblastoma multiforme (GBM) as a model disease.

    This webinar will focus on our efforts to develop screening panels comprising of mutations, epimutations, gene expression, structural variations and copy number variations to stratify patients using small sample input amounts and Next Generation Sequencing technologies.

    Key Learning Objectives:

    • Understand the role of Next Generation Sequencing in personalized medicine
    • How to identify various genomic alterations in rapid time
    • How Next Generation Sequencing can help stratify patient populations

    This webinar is intended for drug development scientists and decision makers with a focus on genomics & next generation sequencing


    Anup Madan, Ph.D., Director of Sequencing, Covance

    Anup Madan, Ph.D. is the Principal Scientist, Genomics/Associate Director, Sequencing Group at Covance. He is responsible for developing Next generation sequencing platform for providing sequence based assays as core services by Covance Genomic Laboratory and as well as developing novel MDx assays to support various clinical trials.

    Anup played a key role in sequencing of human genome and made significant contributions to understand etiology of brain tumors. He has published extensively in reputable journals such as Science, Nature, Cancer Research etc. Anup has a Ph.D. in Biochemical Genetics from Tata Institute of Fundamental Research in Mumbai, India.


    Covance, with headquarters in Princeton, New Jersey, is one of the world's largest and most comprehensive drug development services companies, with annual revenues greater than $2 billion and more than 11,000 employees in more than 60 countries. Covance has the people, processes, client service, and global resource capabilities to respond to biotechnology and pharmaceutical clients' toughest drug development challenges.

    Covance Discovery and Translational Services more effectively and efficiently bridges research gaps by providing integrated solutions throughout preclinical and clinical phases of development. Only Covance drives innovative pipeline development by integrating custom immunology services with early non-clinical safety, efficacy and Discovery services, Biomarkers, Genomics and antibody products.

    For information about the recorded archive for this event contact Xtalks at (416) 977-6555 ext 371, or email register@xtalks.com

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