Upcoming Webinars Archived Webinars Training Vitals Host A Webinar About Get Updates Contact

Inovio’s DNA-Based Zika Vaccine Shows Promise In Preclinical Study

XTALKS VITALS NEWS

Vaccine

Their latest study – the results of which were published in the journal, npj Vaccines – has demonstrated how their synthetic DNA-based vaccine can protect against infection, brain damage and death caused by the Zika virus.

Share this!

November 14, 2016 | by Sarah Hand, M.Sc.

Inovio Pharmaceuticals Inc. is making swift progress in the development of a vaccine to prevent against Zika virus infection. Their latest study – the results of which were published in the journal, npj Vaccines – has demonstrated how their synthetic DNA-based vaccine can protect against infection, brain damage and death caused by the Zika virus.

As transmission of the mosquito-borne Zika virus continues to grow, biotech companies are racing to develop a vaccine. There are currently no regulator-approved vaccines for the prevention of Zika infection, which has been linked to cases of microcephaly and other birth defects in newborns.

Inovio’s DNA-based vaccine was able to confer protection against the Zika virus on 100 percent of animals which were administered the vaccination. This preclinical study also found that the vaccine prevented the Zika-associated degeneration in the hippocampal and cerebral cortex regions of brain, compared to infected animals who were not given the vaccine.



“Our results support the critical importance of immune responses for both preventing infection as well as ameliorating disease caused by the Zika virus,” said Dr. David B. Weiner, lead researcher and Executive Vice President and Director of the Vaccine Center at The Wistar Institute and the W.W. Smith Charitable Trust Professor in Cancer Research at Wistar. “As the threat of Zika continues, these results provide insight into a new aspect of the possibly protective ability of such a vaccine as a preventative approach for Zika infection.”

This preclinical study was the first to test a vaccine in a Zika-succeptible animal model. Previous studies of Zika vaccine candidates have only been performed in animal models that carry a resistance to the virus.

“Working with Wistar, we have clearly demonstrated the power and the speed of our product development platform when we and our collaborators moved our Zika vaccine from the bench to human studies in less than six months, taking advantage of our platform to help in this outbreak situation,” said Dr. J. Joseph Kim, President and CEO of Inovio Pharmaceuticals, Inc.

The Zika vaccine is currently being tested in two human clinical trials, with Phase I results expected to be reported by the end of this year. The vaccine is being developed by Inovio, along with The Wistar Institute, and GeneOne Life Science Inc.


Keywords: Zika, Vaccine, Preclinical


| NEXT ARTICLE | MORE NEWS | BLOGS | VIDEOS | POLLS & QUIZZES | WEBINARS |

Share this with your colleagues!

MORE NEWS
New Self-Injectable Form of Lupus Drug Approved by the FDA

July 25, 2017 - Patients with systemic lupus erythematosus (SLE) will now have the option to self-inject their medication thanks to the FDA approval of GSK’s reformulated lupus drug, Benlysta (belimumab).

Featured In: Biotech News


Canadian Chicken Farmers to Further Reduce Use of Antibiotics

July 24, 2017 - The Chicken Farmers of Canada, a national group dedicated to supporting poultry farmers and helping them meet consumer demand for chicken, has announced their strategy for eliminating the use of certain antimicrobials in meat production.

Featured In: Food News


Neonatal MRI Medical Device Approved by the FDA

July 24, 2017 - Medical device maker Aspect Imaging has received US Food and Drug Administration (FDA) approval for its Embrace Neonatal MRI System.

Featured In: Medical Device News


LEAVE A COMMENT
 
  
THE XTALKS VITALS INDUSTRY BLOG

Manufacturing Control Strategies: What Pharmaceutical and Biotech Companies Need to Know

REGISTER FOR THESE WEBINARS

Outsourcing Pharmacovigilance: Pros and Cons and Lessons Learned


EDC and eSource: Combined for Better Data and Faster Insights


Using Model Reduction to Bridge the Quality Systems Pharmacology-Pharmacometrics Divide


How to Maximize Your Non-GLP Toxicology Studies: A Guide for Optimal Design and Methodology


Copyright © 2016-2017 Honeycomb Worldwide Inc.