Upcoming Webinars Archived Webinars Training Vitals Host A Webinar About Get Updates Contact

Study: Patient Adherence to Alzheimer’s Drugs Needs Improvement


Alzheimer's Disease

A new study conducted by researchers at Indiana University Center for Aging Research and the Regenstrief Institute, has found that patient adherence to Alzheimer’s medications may be lacking.

Share this!

April 13, 2017 | by Sarah Hand, M.Sc.

While there are currently no treatments capable of curing Alzheimer’s disease, a class of drugs called acetylcholinesterase inhibitors are commonly prescribed to dementia patients to help slow the progression of the disease. As with any medication, it’s important that patients adhere to a dosage schedule in order to receive the full benefit of the drug.

A new study conducted by researchers at Indiana University Center for Aging Research and the Regenstrief Institute, has found that patient adherence to Alzheimer’s medications may be lacking. The results of the post-marketing study were published in the Journal of the American Geriatrics Society.

All three of the acetylcholinesterase inhibitors looked at in the study have been approved by the FDA, and require a period of four to six weeks in order to build the patient up to the most effective target dose. According to the researchers on the current study, after 18 weeks only 50 patients of the 196 patients were still taking the acetylcholinesterase inhibitors.

“While these medications do not change the course of the disease, by not getting patients to target doses, we aren't optimizing the potential benefits these medications may provide,” said primary author Dr. Noll Campbell, IU Center for Aging Research and Regenstrief Institute scientist. “Unlike the clinical trials conducted by drug companies for FDA approval, this study was conducted with participants who were taking an average of 8 other medications – what we would call a 'real-world' population – individuals who are sicker than those who typically participate in drug company trials. Having a better understanding of those to whom the drugs are targeted may provide us with greater insight into how to increase benefits and reduce risk.”

Around half of those patients in the study experienced side effects associated with the medications – such as pain, dizziness, vomiting and diarrhea – early on in treatment, which contributed to their decision to stop taking the medications. Cost of medication also played a role in long-term medication adherence; patients were less likely to stop using the drug donepezil, which is often covered under US drug plans.

Patients prescribed one of the other acetylcholinesterase inhibitors, galantamine and rivastigmine, showed a 14 and 17 percent rate of stopping the medication due to cost reasons, respectively. Some of these patients switched to donepezil, and were continued to be monitored in the study to investigate the overall tolerability of the Alzheimer’s medication.

“Physicians should be aware of the impact of side effects, many of which are shared with other medications that the patient is taking, on both the adherence to the medication and quality of life,” said Campbell. “While these drugs aren't the answer to Alzheimer's disease, improving tolerability and adherence may reduce the complications of the disease.”

Overall, 53 percent of patients taking donepezil reached their target dose over the 18 week study period. This is compared to 19 percent for rivastigmine and 5 percent for galantamine.

“The current US drug trial approval process is just too long – typically 17 years – and inefficient with only a 14 percent hit rate from discovery to successful delivery,” said Dr. Malaz Boustani, founder of the Indiana Clinical and Translational Sciences Institute's IU Center for Health Innovation and Implementation Science and senior author on the publication. “We need to test the efficacy of drugs in real-world populations – as we did in this study – at the earliest phase of clinical trials.”

Keywords:  Medication Adherence, Alzheimer's Disease, Disease Progression


Share this with your colleagues!

Canadian Regulator Recalls Pie Shells Over E. Coli Contaminated Flour

April 28, 2017 - Multiple brands of pie and tart shells are being recalled in Canada after the flour used to manufacture them was linked to 28 cases of illness due to infection with E. coli O121.

Featured In: Food News

FDA Sends Warning Letters to Manufacturers of Fake Cancer Drugs

April 27, 2017 - The FDA is cracking down on the sale of illegal cancer drugs by sending warning letters to 14 US companies selling the unapproved products.

Featured In: Life Science News, Drug Safety News

Womb-Like Device Could Increase Survival of Premature Babies

April 27, 2017 - Researchers at the Children's Hospital of Philadelphia (CHOP) have developed a womb-like device which mimics the environmental conditions found inside the uterus.

Featured In: Life Science News, Medical Device News


What Medical Device Manufacturers Need to Know Before Developing a Biological Safety Evaluation


Technology Solutions for Late Phase Research: Optimising Real World Data Assets

Serialization for Late Starters – With Live Industry Research Results

Clinical Not All Antioxidants Are Created Equal: Astaxanthin, The Antioxidant Powerhouse

The New Gold Standards of IRT Delivery for Clinical Trials

Copyright © 2016-2017 Honeycomb Worldwide Inc.