Upcoming Webinars Archived Webinars Training Vitals Host A Webinar About Get Updates Contact

Your Immune System is Written in Your Genes



The study – which was published in the journal, Nature Communications – suggests that genes may play a bigger role in the development of the immune system than previously thought.

Share this!

January 6, 2017 | by Sarah Hand, M.Sc.

According to researchers at King’s College London, almost three quarters of a person’s immune traits are governed by their genetic information. The study – which was published in the journal, Nature Communications – suggests that genes may play a bigger role in the development of the immune system than previously thought.

The researchers used data on 497 pairs of adult female twins collected through the TwinsUK cohort. In analyzing 23,000 immune traits, the researchers found that complex immune responses – known as adaptive immune traits – which develop after a person is exposed to a specific antigen, are strongly influenced by genetics.

“Our genetic analysis resulted in some unusual findings, where adaptive immune responses, which are far more complex in nature, appear to be more influenced by variations in the genome than we had previously thought,” said Dr. Massimo Mangino, lead researcher from King's College London. “In contrast, variation in innate responses (the simple non-specific immune response) more often arose from environmental differences.”

The article also emphasizes the importance of environmental influences – such as diet, microbial exposure and infections – in childhood in developing the innate immune system. The findings could help inform future research in therapies for autoimmune diseases, including psoriasis and rheumatoid arthritis.

“Our results surprisingly showed how most immune responses are genetic, very personalized and finely tuned,” said Professor Tim Spector, Director of the TwinsUK Registry at King's College London. “What this means is that we are likely to respond in a very individualized way to an infection such as a virus - or an allergen such as a house dust mite causing asthma. This may have big implications for future personalized therapy.”

Keywords: Immune System, Autoimmune Disease, Genetics


Share this with your colleagues!

Researchers Identify Role of ApoE4 Gene as Possible Drug Target in Alzheimer’s Disease

September 21, 2017 - A team of neurology researchers at Washington University School of Medicine in St. Louis have found that in the presence of the ApoE4 protein, another protein known as tau forms tangles in the brain which contributes to neuronal damage characteristic of Alzheimer’s disease.

Featured In: Life Science News

New Guidelines Address CAR-T Immunotherapy Toxicities to Prevent Patient Deaths

September 20, 2017 - Clinicians at The University of Texas MD Anderson Cancer Center have published new guidelines in the journal, Nature Reviews Clinical Oncology, which could help in the management of these toxicities.

Featured In: Biotech News, Drug Safety News

Microneedle Skin Patch Could Treat Common Metabolic Disorders

September 19, 2017 - Researchers at Columbia University Medical Center (CUMC) and the University of North Carolina have developed a microneedle skin patch impregnated with a drug capable of converting white fat into calorie-burning brown fat.

Featured In: Medical Device News


Five Reasons Why Toronto is Emerging as a Major Life Sciences Hub


Development and Manufacture of Highly Potent API Drug Products Throughout the Clinical Phases

Innovation through Integration – Providing Next Generation Biomedical Devices and Interconnects

Clinical Payments Case Studies: Improving Efficiency, Cash Management, and Compliance

Why Phase 3 Trials Fail: Oncology Case Studies and Lessons Learned

Copyright © 2016-2017 Honeycomb Worldwide Inc.