Upcoming Webinars Archived Webinars Training Vitals Host A Webinar About Get Updates Contact

Merck to Combine Keytruda and Genexine Vaccine in HPV Cancer Clinical Trial

XTALKS VITALS NEWS

Immunotherapy

The company plans to combine Keytruda with a Genexine-developed vaccine to determine whether the combo is effective against certain types of cervical cancer.

Share this!

November 18, 2016 | by Sarah Hand, M.Sc.

Merck is looking to establish even more value for its PD-L1 inhibitor immunotherapy, Keytruda. The company plans to combine Keytruda with a Genexine-developed vaccine to determine whether the combo is effective against certain types of cervical cancer.

Merck’s cancer immunotherapy drug will be combined with the biotech’s cancer vaccine, GX-188E, in a clinical trial of HPV-induced cervical cancer. Merck plans to begin with a Phase Ib/IIa clinical trial, with the possibility of expansion to a Phase III study.



The collaboration is just the latest in a long line of pair-ups among pharmaceutical and biotech companies looking to combine immunotherapy and cancer vaccines. When used as a monotherapy, Merck’s Keytruda is able to elicit a 12.5 percent response rate in advanced cervical squamous cell cancer. According to Genexine, based in South Korea, the checkpoint inhibitor drug could compliment their cancer vaccine, potentially improving response rates.

Merck and Genexine plan to start their clinical trial in early 2017, with an initial recruitment of up to 40 patients. Genexine’s GX-188E vaccine is also being developed in Phase II clinical trials of cervical intraepithelial neoplasia, as well as in a Phase I trial for HPV-associated cancers.

Merck isn’t the only pharmaceutical company looking to collaborate on these combination therapies. Bristol-Myers Squibb and AstraZeneca have combined their immunotherapy drugs with cancer vaccines from Bavarian Nordic and Inovio, respectively. Success in this space could mean the development of a blockbuster combination.


Keywords: Cancer, HPV, Immunotherapy


| NEXT ARTICLE | MORE NEWS | BLOGS | VIDEOS | POLLS & QUIZZES | WEBINARS |

Share this with your colleagues!

MORE NEWS
Lavazza Acquires Controlling Stake in Canada’s Kicking Horse Coffee

May 26, 2017 - Italian coffee company Lavazza, has secured an 80 percent equity stake in Canadian organic and fair-trade coffee company Kicking Horse Coffee, in a deal worth CAD$215 million.

Featured In: Food News


FDA First: Keytruda Approved for Cancer Treatment Based on Biomarker Alone

May 25, 2017 - For the first time, the FDA has approved a cancer treatment for solid tumors based on the presence of a biomarker, as opposed to specifying a tissue of origin.

Featured In: Biotech News


One Year of Medically Assisted Dying in Canada

May 25, 2017 - In June of 2016, the federal government of Canada passed legislation to legalize medically assisted dying.

Featured In: Life Science News


LEAVE A COMMENT
 
  
THE XTALKS VITALS INDUSTRY BLOG

Top 5 Most Impactful Tweets in Life Sciences During the Last Week

REGISTER FOR THESE WEBINARS

EU IVD Regulation: Top Five Changes for Medical Device Manufacturers to Consider


Thermal Processing Systems for the Food Industry: A Guide to Selecting Thermal Equipment and Technology


Rare Disease & Orphan Drug Development: Cost-Efficient Trial Design to Minimize Cash Burn


eTMF Workflows: Active eTMF to Improve the Quality of Clinical Trials


Copyright © 2016-2017 Honeycomb Worldwide Inc.