Upcoming Webinars Archived Webinars Training Vitals Host A Webinar About Get Updates Contact

Trial Finds Oral Drug Could Become Standard of Care for In Vitro Fertilization



IVF is just one of the many available methods used to assist women with reproductive issues.

Share this!

March 9, 2017 | by Sarah Hand, M.Sc.

Global healthcare and research company, Abbott, has announced the results of their phase III clinical trial assessing the efficacy of oral dydrogesterone in women undergoing in vitro fertilization (IVF). The Lotus I study involved over 1,000 women across 38 international study sites, and found that the drug had similar efficacy and tolerability compared to the standard of care, micronized vaginal progesterone (MVP).

IVF is just one of the many available methods used to assist women with reproductive issues. Dydrogesterone, a progesterone analogue, is used to prepare the uterine lining for implantation of a fertilized egg.

While MVP remains the most common form of the hormone administered in IVF clinics, it can cause unpleasant side effects, including irritation and discharge. Based on the results of the Lotus I clinical trial, oral dydrogesterone could be a viable treatment alternative to MVP.

“The findings from this study have the potential to have important implications for women undergoing IVF,” said Dr. Herman Tournaye, Director of the Center for Reproductive Medicine at Universitair Ziekenhuis Brussel, and lead clinical researcher for the Lotus I study. “We found oral dydrogesterone to be effective, well tolerated and easy to administer – all of which point to it becoming the new preferred treatment option.”

Compared to patients given MVP, those that were randomized to receive oral dydrogesterone showed similar evidence of ongoing pregnancy at 12 weeks gestation. This endpoint was assessed by testing for the presence of a fetal heartbeat.

Pregnancy rates at 12 weeks gestation were 37.6 percent for the oral dydrogesterone treatment group, and 33.1 percent for patients who received MVP. Full findings – including those pertaining to live birth rates – were published in the journal, Human Reproduction.

Currently, oral dydrogesterone manufactured by Abbott is only available in countries outside the US. The drug is currently approved for a number of region-specific indications, including recurrent miscarriage, endometriosis and hormone replacement therapy (HRT).

Keywords: Clinical Trials, IVF, Reproductive Technology


Share this with your colleagues!

Researchers Identify Role of ApoE4 Gene as Possible Drug Target in Alzheimer’s Disease

September 21, 2017 - A team of neurology researchers at Washington University School of Medicine in St. Louis have found that in the presence of the ApoE4 protein, another protein known as tau forms tangles in the brain which contributes to neuronal damage characteristic of Alzheimer’s disease.

Featured In: Life Science News

New Guidelines Address CAR-T Immunotherapy Toxicities to Prevent Patient Deaths

September 20, 2017 - Clinicians at The University of Texas MD Anderson Cancer Center have published new guidelines in the journal, Nature Reviews Clinical Oncology, which could help in the management of these toxicities.

Featured In: Biotech News, Drug Safety News

Microneedle Skin Patch Could Treat Common Metabolic Disorders

September 19, 2017 - Researchers at Columbia University Medical Center (CUMC) and the University of North Carolina have developed a microneedle skin patch impregnated with a drug capable of converting white fat into calorie-burning brown fat.

Featured In: Medical Device News


Five Reasons Why Toronto is Emerging as a Major Life Sciences Hub


Development and Manufacture of Highly Potent API Drug Products Throughout the Clinical Phases

Innovation through Integration – Providing Next Generation Biomedical Devices and Interconnects

Clinical Payments Case Studies: Improving Efficiency, Cash Management, and Compliance

Why Phase 3 Trials Fail: Oncology Case Studies and Lessons Learned

Copyright © 2016-2017 Honeycomb Worldwide Inc.