Upcoming Webinars Archived Webinars Training Vitals Host A Webinar About Get Updates Contact

Antiviral Drug Could Offer New Treatment for Cystic Fibrosis

XTALKS VITALS NEWS

Cystic Fibrosis

While this condition affects approximately 70,000 individuals around the world, there is currently no cure for cystic fibrosis.

Share this!

April 11, 2017 | by Sarah Hand, M.Sc.

Cystic fibrosis is a genetic disorder in which the secretory glands in the lungs overproduce mucus, thereby impeding breathing and increasing the risk of bacterial infections. While this condition affects approximately 70,000 individuals around the world, there is currently no cure for cystic fibrosis.

Now, research led by an international team from George Washington (GW) University, the University of Perugia and the University of Rome, have determined that a drug used to treat viral infections may be effective at slowing cystic fibrosis disease progression. The researchers published their findings in the journal, Nature Medicine.

The drug, thymosin alpha 1 (Tα1), is a synthetic version of a naturally-occurring protein that plays a role in the immune system. As cystic fibrosis affects more than just the lungs – including the liver, pancreas and intestines – researchers are always on the lookout for a drug which would have multiple therapeutic effects.

A mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene is the cause of the inheritable disease. While the protein is responsible for regulating the chloride channel, which balances salt and water levels in the lungs, the cystic fibrosis mutation causes the protein to be degraded.

The prematurely degraded protein does a poor job of regulating the flow of salts into, and out of the cell, leading to inflammation in the lungs. According to the researchers, Tα1 can correct the malfunctions in sodium and water transport in tissue taken from mice with cystic fibrosis.

What’s more, the drug was also effective in human tissue taken from patients with the specific cystic fibrosis-causing mutation. Not only was the drug found to reduce the inflammation associated with cystic fibrosis, but the stability of the CFTR protein was improved.



Tα1 has been approved by various regulators and is marketed as Zadaxin in 35 countries around the world. It’s primarily used to treat viral infections, including HIV. Currently, the drug is not approved by the FDA in the US, however the researchers believe that Zadaxin has an excellent safety profile in the clinic.

“Right now there are multiple treatments for cystic fibrosis, and while these have improved life expectancy dramatically, there is still only a lifespan of about 40 years for patients,” said Dr. Allan L. Goldstein, study co-author and Professor Emeritus in Residence of biochemistry and molecular medicine at the GW School of Medicine and Health Sciences. “No one treatment can stand alone. We developed a single treatment that can potentially correct the genetic defect that causes cystic fibrosis and decrease the inflammation that happens as a result.”


Keywords:  Antiviral, Cystic Fibrosis, Genetic Disorder


| NEXT ARTICLE | MORE NEWS | BLOGS | VIDEOS | POLLS & QUIZZES | WEBINARS |

Share this with your colleagues!

MORE NEWS
Early Alzheimer’s Patients May See Benefit from Anti-Epilepsy Drug

June 27, 2017 - While the processes behind Alzheimer’s disease development aren’t fully understood, recent research has suggested that some cognitive decline could be caused by seizure-like activity in the brains of patients.

Featured In: Clinical Trials News


First Human Colon Organoids Grown in Lab

June 26, 2017 - Using human pluripotent stem cells, researchers at Cincinnati Children's Hospital Medical Center have developed colon-like organoids that can be transplanted into mice.

Featured In: Life Science News


Could Genetic Markers Help Identify Patients at Risk of Opioid Overdose?

June 26, 2017 - Researchers at Erasmus University Medical Center in the Netherlands have identified 10 genes which may help healthcare providers predict which patients could respond poorly to opioid medications.

Featured In: Drug Safety News


LEAVE A COMMENT
 
  
THE XTALKS VITALS INDUSTRY BLOG

Top 5 Most Impactful Tweets in Drug Development During the Last Week

REGISTER FOR THESE WEBINARS

Serialized? Yes. But are Products Still Being Diverted?


Quantitative Protein Profiling in FFPE to Characterize Toxicities Associated with Immune Checkpoint Inhibitors


Are You Choosing the Right Model? A Guide to Selecting Your Next Immuno-Oncology Model


Imaging-based Subtypes of Pancreatic Cancer


Copyright © 2016-2017 Honeycomb Worldwide Inc.